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G protein-coupled receptors
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What's new to Guide to PHARMACOLOGY

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Our latest release includes:

SARS-Cov-2 protein family which includes 13 members and is found under 'anti-infective targets' in our hierarchy
An emerging oncology target, ACSS2, has been added plus two inhibitor probe compounds (彗星加速器下载 and ADG-207).
Updates have also been made to targets across 20+ different protein families
Over 200 ligands are now marked as antibiotic and more than 100 of these have with links to Antibiotic DB
Improvements have been made to ligand summary pages. Key information, such as synonyms, curator comments, links to activity graph and SMILES and InChI Keys have been prioritised.

Please read our latest Database Report (April 2023) - download/view PDF

Latest News and Hot Topics in Pharmacology

All news Our blog 彗星加速器手机版 Hot topics 彗星加速器节点 Latest pairings 彗星加速器免费版ios

GtoMPdb

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Visit the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY portal
Launched in September 2023 to provide optimised access to GtoPdb data for the malaria research community

The Concise Guide to PHARMACOLOGY 2023/20

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Access the table of contents

Please see the 5 minute introductory video on the Concise Guide:

Recent Publications

BJP journal cover

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Alexander SPH, Armstrong J, Davenport AP, Davies JA, Faccenda E, Harding SD, Levi-Schaffer F, Maguire JJ, Pawson AJ, Southan C, Spedding MJ (2023) Br J Pharmacol. doi: 10.1111/bph.15094. 彗星加速器下载

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Mariotti FR, Quatrini L, Munari E, et al. (2023) Br J Pharmacol. [online ahead of print]. doi: 10.1111/bph.15081.

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Leach K, Hannan FM, Josephs TM, Keller AN, Møller TC, Ward DT, Kallay E, Mason RS, Thakker RV, Riccardi D, Conigrave AD, Bräuner-Osborne H (2023) Pharmacol Rev. 72: 558-604.

IUPHAR review article on Structure and Pharmacology of the Apelin Receptor

Read C, Nyimanu D, Williams TL, Huggins DJ, Sulentic P, Macrae RGC, Yang P, Glen RC, Maguire JJ and Davenport AP (2023) Pharmacol Rev. 71: 764-502.

Publication list

Pharmacology Education

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synPHARM

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SynPharm is a database of ligand-responsive protein sequences, derived from interactions from the Guide to PHARMACOLOGY and using data from the Protein Data Bank.

ELIXIR-UK

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The IUPHAR/BPS Guide to PHARMACOLOGY is one of the ELIXIR-UK node services.

Coronavirus

Our coronavirus information page has details of pharmcological strategies aimed at mitigating against COVID-19. The page also contains links to other useful resources and publications.

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Please see our pre-print manuscript on "A rational roadmap for SARS-CoV-2/COVID-19 pharmacotherapeutic research and development"

Celebrating >20 years of Servier support

Servier, a mid-size French Pharmaceutical company, has a long history in pharmacology, and has supported NC-IUPHAR for >20 years with unrestricted educational grants which have permitted the Paris meetings and thus progress of the database.